Formula 82D – TOPICAL DUTASTERIDE
FREQUENTLY ASKED QUESTIONS
WHAT IS TOPICAL DUTASTERIDE, FORMULA 82D “DUTOXIDIL” and Where to Buy?
Formula 82D Topical Dutasteride sometimes referred to as “Dutoxidil” is a specially compounded topical prescription solution designed to help regrow hair. Formula 82D Topical Dutasteride is the most potent topical DHT inhibitor currently available. Formula 82D Topical Dutasteride can reduce scalp DHT by up to 90% by blocking two types of 5-alpha-reductase 5-AR enzymes, Type I and Type II, while causing a near negligible decline in serum DHT which significantly reduces commonly reported side-effects encountered with oral versions of dutasteride or finasteride. It is important to note that finasteride blocks type II 5-AR which is found in the prostate but does not block type I, which is found primarily in the scalp.
Dr. Alan Bauman, the Hair Restoration Physician who pioneered topical finasteride (Formula 82F) in the US, was also the first to prescribe Formula 82D Topical Dutasteride as an adjunct or alternative to other medical hair regrowth treatments. Formula 82D contains FDA-approved growth medications dutasteride 0.75% and minoxidil 5%, which is why it is generally referred to as “Dutoxidil.”
Formula 82D also contains several other beneficial hair-friendly and scalp-friendly ingredients to enhance penetration, reduce inflammation, and neutralize pH. These further enhance the formula’s effectiveness and minimizes potential side effects to improve usability.
Many hair loss patients who are familiar with the powerful DHT lowering effect of dutasteride taken orally ask “is topical dutasteride a viable and effective hair growth treatment?” They also may want to know “does topically applied dutasteride have a lower risk of side effects than an oral version?”
At Bauman Medical, Dr. Alan Bauman, who was the first physician in the US to routinely prescribed compounded finasteride/Formula 82F to his patients, has followed with great interest the powerful effect of oral dutasteride in his patients and also the strong effect and safety of topical finasteride Formula 82F for many years. Now available by prescription, topical dutasteride Formula 82D “Dutoxidil” containing both topical dutasteride and minoxidil in a powerful but scalp-friendly mixture for the scalp for hair growth that minimizes the chances of side effects. Patients report that topical dutasteride Formula 82D is quick-drying, non-greasy, less sticky, and is a substantially more powerful alternative to over-the-counter hair growth medications like rogaine or generic rogaine (minoxidil).
HOW EFFECTIVE IS TOPICAL DUTASTERIDE FORMULA 82D?
A twice-daily dose of minoxidil has been shown to regrow hair in up to 85% of men and 60% of women. Dutasteride, a multiple 5-alpha-reductase inhibitor that was originally approved by the US FDA for medical use in 2001 as a prostate medication, has been approved in South Korea and Japan for the treatment of androgenetic alopecia aka male pattern hair loss. In clinical studies, the oral version of dutasteride has been shown to regrow hair more rapidly and to a greater extent than the highest approved oral dose of finasteride.
By compounding dutasteride and minoxidil together for topical use directly at the area of hair loss, Formula 82D Topical Dutasteride synergizes the positive effects of both medications, while at the same time reducing potential side effects.
WHO SHOULD USE TOPICAL DUTASTERIDE?
Formula 82D Topical Dutasteride is available only through prescription for men and postmenopausal women in the medical management of hair loss.
WILL FORMULA 82D LEAVE MY HAIR GREASY?
No. Formula 82D Topical Dutasteride has been specially compounded to be quickly absorbed into the scalp, so it will not leave the sticky residue common in many other prescription topical dutasteride treatments.
HOW LONG DOES IT TAKE TOPICAL DUTASTERIDE TO WORK?
Hair growth from Formula 82D Topical Dutasteride can be detected in as little as ten weeks, but it may take 6 to 12 months to become noticeable to the naked eye. Routine HairCheck or other measurements are advised to achieve the best results. Do NOT rely only on visible improvements which studies have show lag many months behind the more sensitive measurements that can be performed professionally in the clinic.
DOES FORMULA 82D HAVE ANY SIDE EFFECTS?
Formula 82D was engineered to reduce side effects both topically and systemically. In those with lighter complexions, the scalp may appear more pink with routine use of 82D. This is due to an increase in blood flow and is considered a good indicator that the treatment is working properly. Some users may experience inflammation and tenderness in the scalp, however, these symptoms are extremely rare due to the fact that Formula 82D contains anti-inflammatory ingredients and doesn’t contain propylene glycol, a common irritant found in over-the-counter solutions. For patients concerned about the risk of sexual side effects from oral dutasteride, research and clinical experience suggest that Formula 82D “Dutoxidil” may significantly reduce those risks, similar to the incredibly popular Formula 82F “Finoxidil,” when compared to oral versions of the treatment.
HOW TO USE FORMULA 82D “DUTOXIDIL”
HOW TO APPLY TOPICAL DUTASTERIDE
Formula 82D is applied topically, directly to the scalp on the thinning and at-risk areas before styling.
For most patients, Bauman Medical recommends 30 drops be applied twice daily, however you should use this and any medication only as directed by your physician.
Formula 82D only works through the scalp, so be sure to take care in applying it directly to the scalp by parting and avoiding the hair wherever possible to reduce waste.
Massage is not required, but be careful to cover any trouble areas where improved growth is desired. Common treatment areas include the crown/vertex area, top of the scalp, as well as the frontal and temple areas. Once Formula 82D has been thoroughly applied, allow no less than three hours before showering, swimming, or engaging in any activity that will cause hair to become wet (e.g., rain or sweat) to allow time for complete absorption.
WHAT TO EXPECT
The treated area may tingle when the medication is applied as the formula is absorbed by the scalp. Over time treated areas may appear more pink. This is considered normal, as Formula 82D stimulates circulation and increases blood flow. If severe dryness, flaking, tenderness, or irritation occurs, discontinue use and contact the office for further instructions.
Continue regular application of Formula 82D as directed by your physician in order to maintain results. Effects should be measurable after 3 months, but it may take between 6-12 months for growth to be visible to the naked eye. Bauman Medical recommends that routine HairCheck measurements be performed to ensure that the treatments are working and to chart improvement.
Use Topical Dutasteride only on the scalp. Formula 82D is NOT for oral or internal use. Avoid contact with eyes and sensitive areas. Women of childbearing age should not use or come in contact with Formula 82D, or areas treated by the formula within 3 hours of treatment due to a risk of birth defects. Care should be taken to keep this and all medications away from children.
WHERE TO BUY TOPICAL DUTASTERIDE?
Formula 82D Topical Dutasteride is only available with a prescription. To find out if you are a candidate for Topical Dutasteride Formula 82D and pricing, please request a consultation with renowned board-certified Hair Restoration Physician, Dr. Alan J Bauman MD.
If you or someone you know has hair loss, hair thinning, baldness, or eyebrow / eyelash concerns, click to start either a long-distance virtual consultation OR an in-person, in-office consultation with Dr. Bauman. You can also Ask Dr. Bauman a Question or simply call Bauman Medical Group toll-free 844-GET-HAIR or +1-561-394-0024.
*Each individual's treatment and/or results may vary
Scientific References for Formula 82D Topical Dutasteride
Arif T, Dorjay K, Adil M, Sami M. Dutasteride in Androgenetic Alopecia: An Update. Curr Clin Pharmacol. 2017;12(1):31-35. doi: 10.2174/1574884712666170310111125. PMID: 28294070.
Shanshanwal SJ, Dhurat RS. Superiority of dutasteride over finasteride in hair regrowth and reversal of miniaturization in men with androgenetic alopecia: A randomized controlled open-label, evaluator-blinded study. Indian J Dermatol Venereol Leprol. 2017 Jan-Feb;83(1):47-54. doi: 10.4103/0378-6323.188652. PMID: 27549867.
Gubelin Harcha W, Barboza Martínez J, Tsai TF, Katsuoka K, Kawashima M, Tsuboi R, Barnes A, Ferron-Brady G, Chetty D. A randomized, active- and placebo-controlled study of the efficacy and safety of different doses of dutasteride versus placebo and finasteride in the treatment of male subjects with androgenetic alopecia. J Am Acad Dermatol. 2014 Mar;70(3):489-498.e3. doi: 10.1016/j.jaad.2013.10.049. Epub 2014 Jan 9. PMID: 24411083.
Zhou Z, Song S, Gao Z, Wu J, Ma J, Cui Y. The efficacy and safety of dutasteride compared with finasteride in treating men with androgenetic alopecia: a systematic review and meta-analysis. Clin Interv Aging. 2019 Feb 20;14:399-406. doi: 10.2147/CIA.S192435. PMID: 30863034; PMCID: PMC6388756.
Fertig RM, Gamret AC, Darwin E, Gaudi S. Sexual side effects of 5-α-reductase inhibitors finasteride and dutasteride: A comprehensive review. Dermatol Online J. 2017 Nov 11;23(11):13030/qt24k8q743. PMID: 29447628.
Vañó-Galván S, Saceda-Corralo D, Moreno-Arrones OM, Rodrigues-Barata R, Morales C, Gil-Redondo R, Bernárdez-Guerra C, Hermosa-Gelbard Á, Jaén-Olasolo P. Effectiveness and safety of oral dutasteride for male androgenetic alopecia in real clinical practice: A descriptive monocentric study. Dermatol Ther. 2020 Jan;33(1):e13182. doi: 10.1111/dth.13182. Epub 2019 Dec 18. PMID: 31820540.
Boyapati A, Sinclair R. Combination therapy with finasteride and low-dose dutasteride in the treatment of androgenetic alopecia. Australas J Dermatol. 2013 Feb;54(1):49-51. doi: 10.1111/j.1440-0960.2012.00909.x. Epub 2012 Jun 12. PMID: 22686691.
Olsen EA, Hordinsky M, Whiting D, Stough D, Hobbs S, Ellis ML, Wilson T, Rittmaster RS; Dutasteride Alopecia Research Team. The importance of dual 5alpha-reductase inhibition in the treatment of male pattern hair loss: results of a randomized placebo-controlled study of dutasteride versus finasteride. J Am Acad Dermatol. 2006 Dec;55(6):1014-23. doi: 10.1016/j.jaad.2006.05.007. PMID: 17110217.
Boersma IH, Oranje AP, Grimalt R, Iorizzo M, Piraccini BM, Verdonschot EH. The effectiveness of finasteride and dutasteride used for 3 years in women with androgenetic alopecia. Indian J Dermatol Venereol Leprol. 2014 Nov-Dec;80(6):521-5. doi: 10.4103/0378-6323.144162. PMID: 25382509.
Pindado-Ortega C, Saceda-Corralo D, Moreno-Arrones ÓM, Rodrigues-Barata AR, Hermosa-Gelbard Á, Jaén-Olasolo P, Vañó-Galván S. Effectiveness of dutasteride in a large series of patients with frontal fibrosing alopecia in real clinical practice. J Am Acad Dermatol. 2021 May;84(5):1285-1294. doi: 10.1016/j.jaad.2020.09.093. Epub 2020 Oct 7. PMID: 33038469.
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