HomeNewsPelage PP405 Stimulates Hair Follicle Stem Cells via Mitochondria in Phase 1 Trial

Pelage PP405 Stimulates Hair Follicle Stem Cells via Mitochondria in Phase 1 Trial

Bookmark This Page
Pelage PP405 Stimulates Hair Follicle Stem Cells via Mitochondria in Phase 1 Trial

Unlocking Hair Growth: The Groundbreaking Science Behind PP405’s Stem Cell Activation

Pelage Presents Late-Breaking Data at AAD 2024 Meeting Demonstrating PP405 Activates Human Hair Follicle Stem Cells Ex Vivo and in Phase 1 Clinical Study

March 2024

Pelage Pharmaceuticals presented promising results at the 2024 AAD meeting for their novel hair loss treatment, PP405. This small molecule therapy targets dormant hair follicle stem cells through a metabolic pathway involving mitochondrial pyruvate carriers. The mechanism involves upregulating lactate dehydrogenase (LDH), which in turn activates these stem cells, stimulating hair growth.

Key findings from their Phase 1 clinical trial showed that PP405 is safe and effective. It was well-tolerated by patients with androgenetic alopecia, achieving the target pharmacokinetic profile without detectable drug levels in the blood. Notably, there was a statistically significant increase in Ki67, a marker of cell proliferation, within just seven days of use, indicating active hair follicle stem cell engagement. This early data suggests the treatment might transition hair follicles from a resting phase to a growing phase.

PP405’s potential extends beyond androgenetic alopecia to possibly benefit those with stress-induced hair loss (telogen effluvium) and chemotherapy-induced alopecia. Pelage Pharmaceuticals plans to start a Phase 2a trial in mid-2024, further exploring PP405’s efficacy and safety across different demographics.

Overall, PP405 represents a significant advancement in alopecia treatment, offering a new approach that directly targets hair follicle stem cells to stimulate hair growth. This could be a breakthrough for hair loss patients, offering a new, non-invasive option for restoring hair growth.

 

SOURCE Pelage Pharmaceuticals

PR Newswire

 

If you or someone you know has hair loss, hair thinning, baldness, or eyebrow / eyelash concerns, click to start either a long-distance virtual consultation OR an in-person, in-office consultation with Dr. Bauman. You can also Ask Dr. Bauman a Question or simply call Bauman Medical Group  at +1-561-394-0024.

*Each individual's treatment and/or results may vary

Unlocking Hair Growth: The Groundbreaking Science 
Behind Pelage’s Pp405’S Stem Cell Activation

Unlocking Hair Growth:
The Groundbreaking Science
Behind Pelage’s PP405’s Stem Cell Activation

Post A Comment

Comments are closed here.

Disclaimer: *All patient or client images, videos and testimonials are based on the personal experiences of our patients and represent individual diagnoses, medical conditions, goals and results. Every individual case is unique therefore, results may vary from person to person. All testimonials are provided voluntarily by our patients and clients without monetary compensation and all photos and videos have been consented to for public release and have not been altered in any way. The content contained herein is for education only and should not be considered medical advice. Medical advice may only be given through a one-on-one, private consultation with a physician.

Bauman Medical Group

View Post
X
X

Select Consultation Desired

Hair
Consultation

In Office Virtual

Eyelash / Brow
Consultation

In Office Virtual

You can also Ask Dr. Bauman a Question or call toll-free 844-GET-HAIR or +1-561-394-0024

; ;